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Article

Mitogen-activated protein kinase regulates nuclear association of human progesterone receptors.

Molecular endocrinology (Baltimore, Md.) - 1 Apr 2003

Qiu Ming, Olsen Abby, Faivre Emily, Horwitz Kathryn B, Lange Carol A

Abstract excerpt

Breast cancers often have increased MAPK activity; this pathway may drive breast cancer cell growth by targeting steroid hormone receptors. MAPK phosphorylates human progesterone receptors (PRs) on Ser294, thus regulating several aspects of PR activity. To study the role of PR Ser294 phosphorylation on subcellular distribution, we stably expressed wild-type (wt) or S294A (Ser294 to Ala) PR-B in several cell...

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Identifiers

PMID: 12554776
DOI: 10.1210/me.2002-0378

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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