Article
Phosphorylation of a conserved serine in the deoxyribonucleic acid binding domain of nuclear receptors alters intracellular localization.
Molecular endocrinology (Baltimore, Md.) - 1 Jun 2007
Sun Kai, Montana Vedrana, Chellappa Karthikeyani, Brelivet Yann, Moras Dino, Maeda Yutaka, Parpura Vladimir, Paschal Bryce M, Sladek Frances M
Abstract excerpt
Nuclear receptors (NRs) are a superfamily of transcription factors whose genomic functions are known to be activated by lipophilic ligands, but little is known about how to deactivate them or how to turn on their nongenomic functions. One obvious mechanism is to alter the nuclear localization of the receptors. Here, we show that protein kinase C (PKC) phosphorylates a highly conserved serine (Ser) between the two...
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