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Article

Nuclear translocation of mitochondrial ferredoxin reductase is regulated by AKT-mediated phosphorylation.

The Biochemical journal - 6 May 2026

Nakajima Ken-Ichi, Mohibi Shakur, Chen Xinbin, Zhang Jin

Abstract excerpt

Ferredoxin reductase (FDXR) is the sole ferredoxin reductase in humans and plays an essential role for steroidogenesis and biosynthesis of heme and iron-sulfur cluster (ISC) by transferring electrons from NADPH to ISC-containing ferredoxin 1 (FDX1) and FDX2. In this study, we found that while FDXR is classified as a mitochondria-localized flavoprotein, it can be translocated into the nucleus, especially in...

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Source

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Identifiers

PMID: 41860465
DOI: 10.1042/BCJ20250303
PMCID: PMC13142927

Genes

FDXR
FDX1
FDX2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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