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Article

Serine 350 of human pregnane X receptor is crucial for its heterodimerization with retinoid X receptor alpha and transactivation of target genes in vitro and in vivo.

Biochemical pharmacology - 15 Aug 2015

Wang Yue-Ming, Chai Sergio C, Lin Wenwei, Chai Xiaojuan, Elias Ayesha, Wu Jing, Ong Su Sien, Pondugula Satyanarayana R, Beard Jordan A, Schuetz Erin G, Zeng Su, Xie Wen, Chen Taosheng

Abstract excerpt

The human pregnane X receptor (hPXR), a member of the nuclear receptor superfamily, senses xenobiotics and controls the transcription of genes encoding drug-metabolizing enzymes and transporters. The regulation of hPXR's transcriptional activation of its target genes is important for xenobiotic detoxification and endobiotic metabolism, and hPXR dysregulation can cause various adverse drug effects. Studies have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26119819
DOI: 10.1016/j.bcp.2015.06.018
PMCID: PMC4526351

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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