Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of pregnane X receptor (PXR) function and UGT1A1 gene expression by posttranslational modification of PXR protein.

Drug metabolism and disposition: the biological fate of chemicals - 1 Oct 2012

Sugatani Junko, Uchida Takahiro, Kurosawa Masatoshi, Yamaguchi Masahiko, Yamazaki Yasuhiro, Ikari Akira, Miwa Masao

Abstract excerpt

Human UDP-glucuronosyltransferase (UGT) 1A1 is a critical enzyme responsible for detoxification and metabolism of endogenous and exogenous lipophilic compounds such as bilirubin. The present study shows how cyclin-dependent kinase (CDK) inhibitor roscovitine stimulated the expression of UGT1A1 in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Constitutive Androstane Receptor
Share to Cyclin-Dependent Kinase 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HSP40 Heat-Shock Proteins

Share to Pregnane X Receptor

Share to Purines

Share to Receptors, Aryl Hydrocarbon

Share to Receptors, Steroid

Share to Retinoid X Receptors

Source

Identifiers

PMID: 22829544
DOI: 10.1124/dmd.112.046748

Genes

CDK2
SRC
CDK1
CDK5

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22829544-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of pregnane X receptor (PXR) function and UGT1A1 gene expression by posttranslational modification of PXR protein.PMID 22829544Read ↗

Post-translational and Post-transcriptional Modifications of Pregnane X Receptor (PXR) in Regulation of the Cytochrome P450 SuperfamilySemantic proximity Read ↗

Threonine-290 regulates nuclear translocation of the human pregnane X receptor through its phosphorylation/dephosphorylation by Ca2+/calmodulin-dependent protein kinase II and protein phosphatase 1.Semantic proximity Read ↗

Threonine-408 Regulates the Stability of Human Pregnane X Receptor through Its Phosphorylation and the CHIP/Chaperone-Autophagy Pathway.Semantic proximity Read ↗

Insights into the critical role of the PXR in preventing carcinogenesis and chemotherapeutic drug resistanceSemantic proximity Read ↗

Cyclin-dependent kinase 2 negatively regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells.Semantic proximity Read ↗

Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptorSemantic proximity Read ↗

The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR.Semantic proximity Read ↗

Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes.Semantic proximity Read ↗

Mathematical Models in the Description of Pregnane X Receptor (PXR)-Regulated Cytochrome P450 Enzyme InductionSemantic proximity Read ↗

Identification of pregnane-X receptor target genes and coactivator and corepressor binding to promoter elements in human hepatocytesSemantic proximity Read ↗

Regulation of progesterone receptor activity by cyclin dependent kinases 1 and 2 occurs in part by phosphorylation of the SRC-1 carboxyl-terminus.Semantic proximity Read ↗

Retinoic acid represses CYP7A1 expression in human hepatocytes and HepG2 cells by FXR/RXR-dependent and independent mechanisms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.