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Article

Glucocorticoid receptor phosphorylation differentially affects target gene expression.

Molecular endocrinology (Baltimore, Md.) - 1 Aug 2008

Chen Weiwei, Dang Thoa, Blind Raymond D, Wang Zhen, Cavasotto Claudio N, Hittelman Adam B, Rogatsky Inez, Logan Susan K, Garabedian Michael J

Abstract excerpt

The glucocorticoid receptor (GR) is phosphorylated at multiple sites within its N terminus (S203, S211, S226), yet the role of phosphorylation in receptor function is not understood. Using a range of agonists and GR phosphorylation site-specific antibodies, we demonstrated that GR transcriptional activation is greatest when the relative phosphorylation of S211 exceeds that of S226. Consistent with this finding, a...

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Identifiers

PMID: 18483179
DOI: 10.1210/me.2007-0219
PMCID: PMC2725771

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MED14

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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