Article
A phosphomimetic mutation at threonine-57 abolishes transactivation activity and alters nuclear localization pattern of human pregnane x receptor.
Drug metabolism and disposition: the biological fate of chemicals - 1 Apr 2009
Pondugula Satyanarayana R, Brimer-Cline Cynthia, Wu Jing, Schuetz Erin G, Tyagi Rakesh K, Chen Taosheng
Abstract excerpt
The pregnane X receptor (PXR) plays crucial roles in multiple physiological processes. However, the signaling mechanisms responsible are not well defined; it is most likely that multiple functions of PXR are modulated by its phosphorylation. Therefore, we sought to determine whether mutation at a highly conserved Thr(57) affects human PXR (hPXR) function. Site-directed mutagenesis was performed to generate...
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