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Article

MAP kinase activity supported by BRAF (V600E) mutation rather than gene amplification is associated with ETV1 expression in melanoma brain metastases.

Archives of dermatological research - 1 Dec 2014

Birner Peter, Berghoff Anna S, Dinhof Carina, Pirker Christine, Capper David, Schoppmann Sebastian F, Petzelbauer Peter, von Deimling Andreas, Berger Walter, Preusser Matthias

Abstract excerpt

In primary melanoma, ETV1 transcription factor was suggested to be activated mainly by gene amplification and to promote tumor growth in cooperation with BRAF (V600E) . Aim of this study was to investigate ETV1 expression in human melanoma with a focus on brain metastases. We investigated ETV1 in 68 human melanoma brain metastases using FISH for ETV1 gene (located at chromosome 7p21) and centromere chromosome 7...

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Identifiers

PMID: 25073704
DOI: 10.1007/s00403-014-1490-6

Genes

ETV1
BRAF
CIC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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