Article
BRAF Gene Copy Number and Mutant Allele Frequency Correlate with Time to Progression in Metastatic Melanoma Patients Treated with MAPK Inhibitors.
Molecular cancer therapeutics - 1 Jun 2018
Stagni Camilla, Zamuner Carolina, Elefanti Lisa, Zanin Tiziana, Bianco Paola Del, Sommariva Antonio, Fabozzi Alessio, Pigozzo Jacopo, Mocellin Simone, Montesco Maria Cristina, Chiarion-Sileni Vanna, De Nicolo Arcangela, Menin Chiara
Abstract excerpt
Metastatic melanoma is characterized by complex genomic alterations, including a high rate of mutations in driver genes and widespread deletions and amplifications encompassing various chromosome regions. Among them, chromosome 7 is frequently gained in BRAF-mutant melanoma, inducing a mutant allele-specific imbalance. Although BRAF amplification is a known mechanism of acquired resistance to therapy with MAPK...
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