Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular profiling of patient-matched brain and extracranial melanoma metastases implicates the PI3K pathway as a therapeutic target.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2014

Chen Guo, Chakravarti Nitin, Aardalen Kimberly, Lazar Alexander J, Tetzlaff Michael T, Wubbenhorst Bradley, Kim Sang-Bae, Kopetz Scott, Ledoux Alicia A, Gopal Y N Vashisht, Pereira Cristiano Goncalves, Deng Wanleng, Lee Ju-Seog, Nathanson Katherine L, Aldape Kenneth D, Prieto Victor G, Stuart Darrin, Davies Michael A

Abstract excerpt

PURPOSE: An improved understanding of the molecular pathogenesis of brain metastases, one of the most common and devastating complications of advanced melanoma, may identify and prioritize rational therapeutic approaches for this disease. In particular, the identification of molecular differences...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Neoplasms
Share to DNA Copy Number Variations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTP Phosphohydrolases

Share to Melanoma

Share to Neoplasm Metastasis

Share to Phosphatidylinositol 3-Kinases

Share to Proto-Oncogene Proteins B-raf

Share to Proto-Oncogene Proteins c-akt

Source

Open in PubMed Open full text

Identifiers

PMID: 24803579
DOI: 10.1158/1078-0432.CCR-13-3003
PMCID: PMC4216765

Genes

BRAF
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24803579-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular profiling of patient-matched brain and extracranial melanoma metastases implicates the PI3K pathway as a therapeutic target.PMID 24803579Read ↗

Integrative Genomic Analyses of Patient-Matched Intracranial and Extracranial Metastases Reveal a Novel Brain-Specific Landscape of Genetic Variants in Driver Genes of Malignant MelanomaSemantic proximity Read ↗

Patient-specific identification of genome-wide DNA-methylation differences between intracranial and extracranial melanoma metastasesSemantic proximity Read ↗

Genetic Characterization of Brain Metastases in the Era of Targeted TherapySemantic proximity Read ↗

Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets.Semantic proximity Read ↗

Treatment of brain metastases in the modern genomic era.Semantic proximity Read ↗

Personalized identification and characterization of genome-wide gene expression differences between patient-matched intracranial and extracranial melanoma metastasis pairsSemantic proximity Read ↗

Sequencing brain metastases and opportunities for targeted therapies.Semantic proximity Read ↗

Genomic profiling of brain metastases: current knowledge and new frontiers.Semantic proximity Read ↗

DNA methylation and gene deletion analysis of brain metastases in melanoma patients identifies mutually exclusive molecular alterations.Semantic proximity Read ↗

Targeting hyperactivation of the AKT survival pathway to overcome therapy resistance of melanoma brain metastases.Semantic proximity Read ↗

The mutational landscape of melanoma brain metastases presenting as the first visceral site of recurrence.Semantic proximity Read ↗

Next-Generation Sequencing of Stage IV Squamous Cell Lung Cancers Reveals an Association of PI3K Aberrations and Evidence of Clonal Heterogeneity in Patients with Brain Metastases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.