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Article

Intra- and Inter-Tumoral Homogeneity of BRAF(V600E) Mutations in Melanoma Tumors.

The Journal of investigative dermatology - 1 Dec 2015

Riveiro-Falkenbach Erica, Villanueva Cándida A, Garrido María C, Ruano Yolanda, García-Martín Rosa M, Godoy Elena, Ortiz-Romero Pablo L, Ríos-Martín Juan J, Santos-Briz Angel, Rodríguez-Peralto José L

Abstract excerpt

The era of targeted therapy has introduced a new therapeutic perspective for melanoma patients. Treatment with BRAFV600 inhibitors has improved overall and disease-free survival in metastatic melanoma patients whose tumors harbor BRAFV600 mutations. Although the BRAFV600E mutation appears to have a critical role in tumor initiation, its expression during tumor progression remains controversial. In fact, various...

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Identifiers

PMID: 26083553
DOI: 10.1038/jid.2015.229

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BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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