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Article

Clinical neuropathology practice news 2-2012: BRAF V600E testing.

Clinical neuropathology - 1 Jan 2000

Capper David, Berghoff Anna-Sophie, von Deimling Andreas, Preusser Matthias

Abstract excerpt

Activating mutations of the serine threonine kinase v-RAF murine sarcoma viral oncogene homologue B1 (BRAF), most commonly of the V600E type, are found in a wide range of human neoplasms including primary and secondary brain tumors. Therapeutic BRAF inhibitors have shown clinically meaningful activity, particularly in metastatic BRAF V600E mutated melanoma including patients with brain metastases. Therefore, in...

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Identifiers

PMID: 22385786
DOI: 10.5414/np300492
PMCID: PMC3663457

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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