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Article

Immunohistochemical testing of BRAF V600E status in 1,120 tumor tissue samples of patients with brain metastases.

Acta neuropathologica - 1 Feb 2012

Capper David, Berghoff Anna Sophie, Magerle Manuel, Ilhan Aysegül, Wöhrer Adelheid, Hackl Monika, Pichler Josef, Pusch Stefan, Meyer Jochen, Habel Antje, Petzelbauer Peter, Birner Peter, von Deimling Andreas, Preusser Matthias

Abstract excerpt

Brain metastases (BM) are frequent and carry a dismal prognosis. BRAF V600E mutations are found in a broad range of tumor types and specific inhibitors targeting BRAF V600E protein exist. We analyzed tumoral BRAF V600E-mutant protein expression using the novel mutation-specific antibody VE1 in a series of 1,120 tumor specimens (885 BM, 157 primary tumors, 78 extra-cranial metastases) of 874 BM patients. In 85...

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Identifiers

PMID: 22012135
DOI: 10.1007/s00401-011-0887-y

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BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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