Article
A Retrospective Evaluation of Vemurafenib as Treatment for BRAF-Mutant Melanoma Brain Metastases.
The oncologist - 1 Jul 2015
Harding James J, Catalanotti Federica, Munhoz Rodrigo R, Cheng Donavan T, Yaqubie Amin, Kelly Nicole, McDermott Gregory C, Kersellius Romona, Merghoub Taha, Lacouture Mario E, Carvajal Richard D, Panageas Katherine S, Berger Michael F, Rosen Neal, Solit David B, Chapman Paul B
Abstract excerpt
BACKGROUND: RAF inhibitors are an effective therapy for patients with BRAF-mutant melanoma and brain metastasis. Efficacy data are derived from clinical studies enriched with physiologically fit patients; therefore, it is of interest to assess the real-world experience of vemurafenib in this population. Tumor-specific genetic variants that influence sensitivity to RAF kinase inhibitors also require investigation....
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