Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Involvement of overexpressed wild-type BRAF in the growth of malignant melanoma cell lines.

Oncogene - 18 Nov 2004

Tanami Hideaki, Imoto Issei, Hirasawa Akira, Yuki Yasuhiro, Sonoda Itaru, Inoue Jun, Yasui Kohichiro, Misawa-Furihata Akiko, Kawakami Yutaka, Inazawa Johji

Abstract excerpt

Comparative genomic hybridization (CGH) using 40 cell lines derived from malignant melanomas (MMs) revealed frequent amplification at 7q33-q34 containing BRAF gene, which often is mutated in MM. We found this gene to be amplified to a remarkable degree in the MM cell lines that exhibited high-lev...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Division
Share to Chromosomes, Human, Pair 7
Share to Genes, ras

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Melanoma

Share to Mitogen-Activated Protein Kinases

Share to Nucleic Acid Hybridization

Share to Proto-Oncogene Proteins B-raf

Share to Skin Neoplasms

Source

Identifiers

PMID: 15467732
DOI: 10.1038/sj.onc.1208152

Genes

BRAF
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15467732-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Involvement of overexpressed wild-type BRAF in the growth of malignant melanoma cell lines.PMID 15467732Read ↗

MAP kinase activity supported by BRAF (V600E) mutation rather than gene amplification is associated with ETV1 expression in melanoma brain metastases.Semantic proximity Read ↗

BRAF Gene Copy Number and Mutant Allele Frequency Correlate with Time to Progression in Metastatic Melanoma Patients Treated with MAPK Inhibitors.Semantic proximity Read ↗

Expression of FGF1 and FGFR1 in human melanoma tissuesSemantic proximity Read ↗

Emerging BRAF Mutations in Cancer Progression and Their Possible Effects on Transcriptional Networks.Semantic proximity Read ↗

Marked genetic differences between BRAF and NRAS mutated primary melanomas as revealed by array comparative genomic hybridization.Semantic proximity Read ↗

Aberrant B-Raf signaling in human cancer -- 10 years from bench to bedside.Semantic proximity Read ↗

[Characterization of genetic alterations in primary human melanomas carrying BRAF or NRAS mutation].Semantic proximity Read ↗

Hyperactivation of MAPK Signaling Is Deleterious to RAS/RAF-mutant Melanoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.