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Article

BRAF-V600 mutational status affects recurrence patterns of melanoma brain metastasis.

International journal of cancer - 15 Jun 2017

Maxwell Russell, Garzon-Muvdi Tomas, Lipson Evan J, Sharfman William H, Bettegowda Chetan, Redmond Kristin J, Kleinberg Lawrence R, Ye Xiaobu, Lim Michael

Abstract excerpt

Brain metastasis is common and carries a poor prognosis in melanoma. A single institution, retrospective cohort of 225 melanoma patients was analyzed to determine if BRAF-V600 mutational status was associated with brain metastasis. Eighty-three of the 225 patients (37%) had BRAF-V600 mutations. At initial diagnosis, BRAF-V600 mutations were associated with younger age (p ≤ 0.001), higher proportion of females...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Multivariate Analysis

Share to Neoplasm Recurrence, Local

Share to Protein Kinase Inhibitors

Share to Proto-Oncogene Proteins B-raf

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Source

Identifiers

PMID: 27342756
DOI: 10.1002/ijc.30241

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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