Article
Amplification of AML1 gene is present in childhood acute lymphoblastic leukemia but not in adult, and is not associated with AML1 gene mutation.
Leukemia - 1 Jun 2002
Penther D, Preudhomme C, Talmant P, Roumier C, Godon A, Méchinaud F, Milpied N, Bataille R, Avet-Loiseau H
Abstract excerpt
The AML1/CBFA2/RUNX1 gene is the target of many recurrent translocations seen in different leukemia subtypes. The t(12;21)(p13;q22) is the most frequent translocation observed in childhood B acute lymphoblastic leukemia (ALL), occurring in 20% to 25% of cases. In adult ALL this rearrangement is scarce. Another route of AML1deregulation could be point mutations in the runt domain. We now report on...
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