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Article

New mechanisms of AML1 gene alteration in hematological malignancies.

Leukemia - 1 Jan 2003

Roumier C, Fenaux P, Lafage M, Imbert M, Eclache V, Preudhomme C

Abstract excerpt

The human AML1 gene (also named CBFA2 or RUNX1), located in the 21q22 chromosomal band, encodes for one of the two subunits forming a heterodimeric transcription factor, the human core binding factor (CBF). AML1 protein contains a highly evolutionary conserved domain of 128 amino acids called runt domain, responsible for both heterodimerization with the beta subunit of CBF and for DNA binding. AML1 is normally...

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Share to Chromosomes, Human, Pair 21
Share to Core Binding Factor Alpha 2 Subunit
Share to Gene Amplification

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myeloid

Share to Myelodysplastic Syndromes

Share to Oncogene Proteins, Fusion

Share to RUNX1 Translocation Partner 1 Protein

Share to Translocation, Genetic

Source

Identifiers

PMID: 12529654
DOI: 10.1038/sj.leu.2402766

Genes

RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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