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Article

Point mutations in the RUNX1/AML1 gene: another actor in RUNX leukemia.

Oncogene - 24 May 2004

Osato Motomi

Abstract excerpt

The RUNX1/AML1 gene is the most frequent target for chromosomal translocation in leukemia. In addition, recent studies have demonstrated point mutations in the RUNX1 gene as another mode of genetic alteration in development of leukemia. Monoallelic germline mutations in RUNX1 result in familial platelet disorder predisposed to acute myelogenous leukemia (FPD/AML). Sporadic point mutations are frequently found in...

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Source

Identifiers

PMID: 15156185
DOI: 10.1038/sj.onc.1207779

Genes

RUNX1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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