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Article

AML1/RUNX1 mutations are infrequent, but related to AML-M0, acquired trisomy 21, and leukemic transformation in pediatric hematologic malignancies.

Genes, chromosomes & cancer - 1 Sept 2003

Taketani Takeshi, Taki Tomohiko, Takita Junko, Tsuchida Masahiro, Hanada Ryoji, Hongo Teruaki, Kaneko Takashi, Manabe Atsushi, Ida Kohmei, Hayashi Yasuhide

Abstract excerpt

AML1/RUNX1, located on chromosome band 21q22, is one of the most important hematopoietic transcription factors. AML1 is frequently affected in leukemia and myelodysplastic syndrome with 21q22 translocations. Recently, AML1 mutations were found in adult hematologic malignancies, especially acute myeloid leukemia (AML)-M0 or leukemia with acquired trisomy 21, and familial platelet disorder with a predisposition...

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Source

Identifiers

PMID: 12874780
DOI: 10.1002/gcc.10246

Genes

RUNX1
SCT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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AML1/RUNX1 mutations are infrequent, but related to AML-M0, acquired trisomy 21, and leukemic transformation in pediatric hematologic malignancies.PMID 12874780Read ↗

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