Article
Mutations of AML1 in non-M0 acute myeloid leukemia: six novel mutations and a high incidence of cooperative events in a South-east Asian population.
Haematologica - 1 May 2006
Auewarakul Chirayu U, Leecharendkeat Amporn, Thongnoppakhun Wanna, Limwongse Chanin, Tocharoentanaphol Chintana
Abstract excerpt
Point mutations of AML1 are uncommon and predominantly reported in a rare minimally differentiated acute myeloid leukemia (M0 AML). Few data exist regarding the frequency of AML1 mutations in non-M0 cases. We screened 284 consecutive adult Thai patients with de novo AML and found that 3.9% had AML1 mutations. The highest incidence occurred in M6. Six novel mutations were uniquely identified in non-M0 cases....
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