Article
WT1 mutations and polymorphisms in Southeast Asian acute myeloid leukemia.
Experimental and molecular pathology - 1 Dec 2011
Lauhakirti Darat, Sritana Narongrit, Boonthimat Chetsada, Promsuwicha Orathai, Auewarakul Chirayu U
Abstract excerpt
Genomic alterations of the Wilms' Tumor 1 (WT1) gene have been reported to occur in patients with acute myeloid leukemia (AML). No data presently exists regarding the frequency of WT1 mutations in the Southeast Asian AML population. This study focused on WT1 exons 7-10 mutations and their correlation with other molecular markers and patients' characteristics. The zinc finger domain of WT1 gene covering exons 7-10...
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