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Article

High expression of cystine-glutamate antiporter xCT (SLC7A11) is an independent biomarker for epileptic seizures at diagnosis in glioma.

Journal of neuro-oncology - 1 May 2018

Sørensen Mai Froberg, Heimisdóttir Sólborg Berglind, Sørensen Mia Dahl, Mellegaard Casper Schau, Wohlleben Helle, Kristensen Bjarne Winther, Beier Christoph Patrick

Abstract excerpt

Epileptic seizures are an important cause of morbidity in glioma patients. Substantial lines of evidence support the concept of the excitatory neurotransmitter glutamate being a crucial mediator of glioma-associated seizures. In gliomas, non-vesicular secretion of glutamate via the cystine-glutamate exchanger (SLC7A11, xCT) constitutes the main mechanism contributing to high extracellular glutamate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29404978
DOI: 10.1007/s11060-018-2785-9

Genes

IDH1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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