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Article

Mutant LGI1 inhibits seizure-induced trafficking of Kv4.2 potassium channels.

Journal of neurochemistry - 1 Feb 2012

Smith Stephen E P, Xu Lin, Kasten Michael R, Anderson Matthew P

Abstract excerpt

Activity-dependent redistribution of ion channels mediates neuronal circuit plasticity and homeostasis, and could provide pro-epileptic or compensatory anti-epileptic responses to a seizure. Thalamocortical neurons transmit sensory information to the cerebral cortex and through reciprocal corticothalamic connections are intensely activated during a seizure. Therefore, we assessed whether a seizure alters ion...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22122031
DOI: 10.1111/j.1471-4159.2011.07605.x
PMCID: PMC3261618

Genes

LGI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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