Article
Disruption of Runx1 and Runx3 leads to bone marrow failure and leukemia predisposition due to transcriptional and DNA repair defects.
Cell reports - 7 Aug 2014
Wang Chelsia Qiuxia, Krishnan Vaidehi, Tay Lavina Sierra, Chin Desmond Wai Loon, Koh Cai Ping, Chooi Jing Yuan, Nah Giselle Sek Suan, Du Linsen, Jacob Bindya, Yamashita Namiko, Lai Soak Kuan, Tan Tuan Zea, Mori Seiichi, Tanuichi Ichiro, Tergaonkar Vinay, Ito Yoshiaki, Osato Motomi
Abstract excerpt
The RUNX genes encode transcription factors involved in development and human disease. RUNX1 and RUNX3 are frequently associated with leukemias, yet the basis for their involvement in leukemogenesis is not fully understood. Here, we show that Runx1;Runx3 double-knockout (DKO) mice exhibited lethal phenotypes due to bone marrow failure and myeloproliferative disorder. These contradictory clinical manifestations...
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