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Oncogenic RUNX3: A Link between p53 Deficiency and MYC Dysregulation.

29 Feb 2020

Abstract excerpt

The RUNX transcription factors serve as master regulators of development and are frequently dysregulated in human cancers. Among the three family members, RUNX3 is the least studied, and has long been considered to be a tumor-suppressor gene in human cancers. This idea is mainly based on the observation that RUNX3 is inactivated by genetic/epigenetic alterations or protein mislocalization during the initiation of...

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PMID: 31991537
DOI: 10.14348/molcells.2019.0285

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