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Cbfb Regulates Bone Development by Stabilizing Runx Family Proteins

29 Sept 2014

Abstract excerpt

Runx family proteins, Runx1, Runx2, and Runx3, play important roles in skeletal development. Runx2 is required for osteoblast differentiation and chondrocyte maturation, and haplodeficiency of RUNX2 causes cleidocranial dysplasia, which is characterized by open fontanelles and sutures and hypoplastic clavicles. Cbfb forms a heterodimer with Runx family proteins and enhances their DNA-binding capacity....

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PMID: 25262822
DOI: 10.1002/jbmr.2379

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