Runx1/AML-1 Ranks as a Master Regulator of Adult Hematopoiesis

Abstract excerpt

Runx1 (AML-1) is a critical gene involved in human leukemogenesis, originally identified at the 21q22 breakpoint of the leukemic translocations of t(8;21)(q21;q22), and is thought to be involved in as much as 25% of human leukemia. It encodes a transcription factor that has close homology to a Drosophila protein, runt, and is found to play essential roles in regulation of hematopoietic systems. Really a gene...

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