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Article

Tau phosphorylation sites work in concert to promote neurotoxicity in vivo.

Molecular biology of the cell - 1 Dec 2007

Steinhilb Michelle L, Dias-Santagata Dora, Fulga Tudor A, Felch Daniel L, Feany Mel B

Abstract excerpt

Tau is a microtubule binding protein implicated in a number of human neurodegenerative disorders, including Alzheimer's disease. Phosphorylation of serine-proline/threonine-proline sites, targeted by proline-directed kinases, coincides temporally with neurodegeneration in the human diseases. Recently, we demonstrated that this unique group of serines and threonines has a critical role in controlling tau toxicity...

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Source

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Identifiers

PMID: 17928404
DOI: 10.1091/mbc.e07-04-0327
PMCID: PMC2096612

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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