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Article

Zinc Exacerbates Tau Pathology in a Tau Mouse Model.

Journal of Alzheimer's disease : JAD - 1 Jan 2018

Craven Kristen M, Kochen William R, Hernandez Carlos M, Flinn Jane M

Abstract excerpt

Hyperphosphorylated tau protein is a key pathology in Alzheimer's disease (AD), frontotemporal dementia, chronic traumatic encephalopathy, and Parkinson's disease. The essential trace element zinc exacerbates tauopathy in vitro as well as in a Drosophila model of AD. However, the interaction has never been assessed behaviorally or biochemically in mammals. Zinc supplementation is prevalent in society, finding use...

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PMID: 29914030
DOI: 10.3233/JAD-180151

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