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Article

Targeting metals rescues the phenotype in an animal model of tauopathy

1 Jan 2018

Abstract excerpt

Tauopathies are characterized by the pathological accumulation of the microtubule associated protein tau within the brain. We demonstrate here that a copper/zinc chaperone (PBT2, Prana Biotechnology) has rapid and profound effects in the rTg(tauP301L)4510 mouse model of tauopathy. This was evidenced by significantly improved cognition, a preservation of neurons, a decrease in tau aggregates and a decrease in...

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PMID: 30168573
DOI: 10.1039/c8mt00153g

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