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Article

Heterogeneous tumor subpopulations cooperate to drive invasion.

Cell reports - 7 Aug 2014

Chapman Anna, Fernandez del Ama Laura, Ferguson Jennifer, Kamarashev Jivko, Wellbrock Claudia, Hurlstone Adam

Abstract excerpt

Clonal selection and transcriptional reprogramming (e.g., epithelial-mesenchymal transition or phenotype switching) are the predominant theories thought to underlie tumor progression. However, a "division of labor" leading to cooperation among tumor-cell subpopulations could be an additional catalyst of progression. Using a zebrafish-melanoma xenograft model, we found that in a heterogeneous setting, inherently...

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Identifiers

PMID: 25066122
DOI: 10.1016/j.celrep.2014.06.045
PMCID: PMC4542310

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MITF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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