Article

Restraint of melanoma progression by cells in the local skin environment

2024-08-19

Abstract excerpt

Keratinocytes, the dominant cell type in the melanoma microenvironment during tumor initiation, exhibit diverse effects on melanoma progression. Using a zebrafish model of melanoma and human cell co-cultures, we observed that keratinocytes undergo an EMT-like transformation in the presence of melanoma, reminiscent of their behavior during wound healing. Surprisingly, overexpression of the EMT transcription factor...

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Identifiers and source

Literature Corpus work: 11f18f27-3030-5ee8-9adb-73454d7566ee
DOI: 10.1101/2024.08.15.608067

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