Article
Diversity in cancer invasion phenotypes indicates specific stroma regulated programs.
Human cell - 1 Jan 2021
Novin Ashkan, Suhail Yasir, Ajeti Visar, Goyal Ruchi, Wali Khadija, Seck Atta, Jackson Alex, Kshitiz
Abstract excerpt
Tumor dissemination into the surrounding stroma is the initial step in a metastatic cascade. Invasion into stroma is a non-autonomous process for cancer, and its progression depends upon the stage of cancer, as well as the cells residing in the stroma. However, a systems framework to understand how stromal fibroblasts resist, collude, or aid cancer invasion has been lacking, limiting our understanding of the role...
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