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Article

Cooperative cell invasion: matrix metalloproteinase–mediated incorporation between cells

8 Sept 2016

Abstract excerpt

Progression to metastatic disease is a leading cause of cancer death. Tumors are a complex mixture of cell types, both genetically heterogeneous malignant cells and associated nonmalignant cells. Models mimicking this heterogeneous cell environment have revealed that invasive cell populations can induce dissemination by otherwise poorly/noninvasive tumor cells, known as cooperative invasion. Neuroblastoma tumors...

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PMID: 27605703
DOI: 10.1091/mbc.e16-03-0194

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