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Article

Tumour heterogeneity promotes collective invasion and cancer metastatic dissemination

1 Aug 2017

Abstract excerpt

Heterogeneity within tumour cell populations is commonly observed in most cancers. However, its impact on metastatic dissemination, one of the primary determinants of the disease prognosis, remains poorly understood. Working with a simplified numerical model of tumour spheroids, we investigated the impact of mechanical heterogeneity on the onset of tumour invasion into surrounding tissues. Our work establishes a...

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PMID: 28878958
DOI: 10.1098/rsos.161007

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