Article

The integration of Tgfβ and Egfr signaling programs confers the ability to lead heterogeneous collective invasion

2020-11-15

Abstract excerpt

<h4>ABSTRACT</h4> Phenotypic heterogeneity promotes tumor evolution and confounds treatment. Minority subpopulations of trailblazer cells enhance the heterogeneity of invading populations by creating paths in extracellular matrix (ECM) that permit the invasion of phenotypically diverse siblings. The regulatory programs that induce a trailblazer state are poorly understood. Here, we define a new Tgfβ induced trail...

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Literature Corpus work: f9e65a77-4027-5af7-864b-6ffdb9977f3a
DOI: 10.1101/2020.11.14.383232

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