Article

Synergistic Cooperation Involving TGFβ1-mediated Crosstalk Enhances the Invasiveness of Genetically Distant Cancer Clones<strong></strong>

2022-11-14

Abstract excerpt

Intratumour heterogeneity is often associated with poor response to treatment and bad prognosis. In addition to constitutive genetic/epigenetic sources, phenotypic and functional heterogeneity can reflect cell plasticity due to changes in gene expression patterns induced by signals from the tumour microenvironment or other cells. Positive interactions between cancer clones can increase their fitness and contribute...

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Literature Corpus work: d5f7cdd1-28f3-5357-872d-92c5d495699d
DOI: 10.20944/preprints202210.0023.v2

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