Article
Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies.
Cell - 31 Jul 2014
Gao Feng, Bonsignori Mattia, Liao Hua-Xin, Kumar Amit, Xia Shi-Mao, Lu Xiaozhi, Cai Fangping, Hwang Kwan-Ki, Song Hongshuo, Zhou Tongqing, Lynch Rebecca M, Alam S Munir, Moody M Anthony, Ferrari Guido, Berrong Mark, Kelsoe Garnett, Shaw George M, Hahn Beatrice H, Montefiori David C, Kamanga Gift, Cohen Myron S, Hraber Peter, Kwong Peter D, Korber Bette T, Mascola John R, Kepler Thomas B, Haynes Barton F
Abstract excerpt
Development of strategies for induction of HIV-1 broadly neutralizing antibodies (bnAbs) by vaccines is a priority. Determining the steps of bnAb induction in HIV-1-infected individuals who make bnAbs is a key strategy for immunogen design. Here, we study the B cell response in a bnAb-producing individual and report cooperation between two B cell lineages to drive bnAb development. We isolated a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.