Article
Functional analysis of single-nucleotide polymorphisms in the regulation of coactivator-associated arginine methyltransferase 1 expression and plasma homocysteine levels.
Circulation. Cardiovascular genetics - 1 Oct 2014
Liu Xuehui, Hao Yongchen, Wang Laiyuan, Li Hongfan, Lu Xiangfeng, Cao Jie, Hu Yongyan, Mo Xingbo, Peng Xiaozhong, Gu Dongfeng
Abstract excerpt
BACKGROUND: Hyperhomocysteinemia is a risk factor for cardiovascular disease. Coactivator-associated arginine methyltransferase 1 (CARM1) participates in the synthesis of homocysteine, but whether the genetic variations regulate CARM1 expression and homocysteine levels remains unknown. METHODS AND RESULTS: Functional analyses combined with an association study were conducted to identify the causal variant for...
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