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Article

Genetic variants in S-adenosyl-methionine synthesis pathway and nonsyndromic cleft lip with or without cleft palate in Chile.

Pediatric research - 1 Mar 2021

Salamanca Carlos, González-Hormazábal Patricio, Recabarren Andrea S, Recabarren Pamela A, Pantoja Roberto, Leiva Noemi, Pardo Rosa, Suazo José

Abstract excerpt

BACKGROUND: The S-adenosyl-methionine (SAM) availability is crucial for DNA methylation, an epigenetic mechanism involved in nonsyndromic cleft lip with or without cleft palate (NSCL/P) expression. The aim of this study was to assess the association between single-nucleotide polymorphisms (SNPs) of genes involved in SAM synthesis and NSCL/P in a Chilean population. METHODS: In 234 cases and 309 controls, 18 SNPs...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32492698
DOI: 10.1038/s41390-020-0994-3

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