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Article

The human MTHFR rs4846049 polymorphism increases coronary heart disease risk through modifying miRNA binding.

Nutrition, metabolism, and cardiovascular diseases : NMCD - 1 Jul 2013

Wu C, Gong Y, Sun A, Zhang Y, Zhang C, Zhang W, Zhao G, Zou Y, Ge J

Abstract excerpt

BACKGROUND AND AIMS: Abnormal functioning of 5,10-methylenetetrahydrofolate reductase (MTHFR) enhances the risk for coronary heart disease (CHD). Here, we tested whether a single-nucleotide polymorphism (SNP) located in the 3' untranslated region (UTR) of MTHFR was associated with CHD susceptibility by affecting microRNAs binding. METHODS AND RESULTS: We first analyzed in silico the SNPs localized in the 3' UTR...

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Share to 3' Untranslated Regions
Share to Apolipoproteins A

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cholesterol, HDL

Share to Coronary Disease

Share to Down-Regulation

Share to Leukocytes, Mononuclear

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to RNA Processing, Post-Transcriptional

Source

Identifiers

PMID: 22647417
DOI: 10.1016/j.numecd.2012.02.009

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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