Article
Functional polymorphism and differential regulation of CYSLTR1 transcription in human airway smooth muscle and monocytes.
Cell biochemistry and biophysics - 1 Jan 2007
Duroudier Nathalie P, Sayers Ian, Castagna Charlotte Carabott, Fenech Anthony G, Halapi Eva, Swan Caroline, Hall Ian P
Abstract excerpt
Cysteinyl leukotrienes play an important role in the pathophysiology of many inflammatory disorders, including asthma. The aim of this study was to characterize the mechanisms underlying transcriptional regulation of the human cysteinyl leukotriene receptor 1 (hCYSLTR1) gene. 5'RACE was performed on human airway smooth muscle (HASM) and peripheral blood mononuclear cells. A1128-bp region of the hCYSLTR1 main...
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