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Article

Single nucleotide polymorphism creating a variable upstream open reading frame regulates glucocorticoid receptor expression.

Gene - 25 May 2015

Marceca Claudia, Pfob Martina, Schelling Gustav, Steinlein Ortrud K, Eggert Marlene

Abstract excerpt

The glucocorticoid and mineralocorticoid receptors are known to play a crucial role in cellular responses to acute and chronic stress conditions. However, the influence of genetic variants and regulatory mechanisms within the glucocorticoid and mineralocorticoid receptor genes NR3C1 and NR3C2 is still incompletely understood. We therefore investigated putative upstream open reading frames, a motif regulating gene...

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PMID: 25771224
DOI: 10.1016/j.gene.2015.03.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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