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Article

Genetic variants reducing MTR gene expression increase the risk of congenital heart disease in Han Chinese populations.

European heart journal - 1 Mar 2014

Zhao Jian-Yuan, Qiao Bin, Duan Wen-Yuan, Gong Xiao-Hong, Peng Qian-Qian, Jiang Song-Shan, Lu Chen-Qi, Chen Yi-Jiang, Shen Hong-Bing, Huang Guo-Ying, Jin Li, Wang Hong-Yan

Abstract excerpt

AIMS: Elevated homocysteine levels are known to be a risk factor for congenital heart disease (CHD), but the mechanism underlying this effect is unknown. During early embryonic development, homocysteine removal is dictated exclusively by the MTR activity. To examine the role of MTR in CHD risk, we identified genetic variants in MTR and investigated the mechanisms that affect its expression levels and that...

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Share to 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ferredoxin-NADP Reductase

Share to Heart Defects, Congenital

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Source

Identifiers

PMID: 23798577
DOI: 10.1093/eurheartj/eht221

Genes

MTR

Provenance

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