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Article

The HIV-1 integrase mutant R263A/K264A is 2-fold defective for TRN-SR2 binding and viral nuclear import.

The Journal of biological chemistry - 5 Sept 2014

De Houwer Stéphanie, Demeulemeester Jonas, Thys Wannes, Rocha Susana, Dirix Lieve, Gijsbers Rik, Christ Frauke, Debyser Zeger

Abstract excerpt

Transportin-SR2 (Tnpo3, TRN-SR2), a human karyopherin encoded by the TNPO3 gene, has been identified as a cellular cofactor of HIV-1 replication, specifically interacting with HIV-1 integrase (IN). Whether this interaction mediates the nuclear import of HIV remains controversial. We previously characterized the TRN-SR2 binding interface in IN and introduced mutations at these positions to corroborate the...

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Source

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Identifiers

PMID: 25063804
DOI: 10.1074/jbc.M113.533281
PMCID: PMC4155696

Genes

TNPO3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The HIV-1 integrase mutant R263A/K264A is 2-fold defective for TRN-SR2 binding and viral nuclear import.PMID 25063804Read ↗

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