Article
Inhibition of HIV-1 infection by TNPO3 depletion is determined by capsid and detectable after viral cDNA enters the nucleus.
Retrovirology - 6 Dec 2011
De Iaco Alberto, Luban Jeremy
Abstract excerpt
BACKGROUND: HIV-1 infects non-dividing cells. This implies that the virus traverses the nuclear pore before it integrates into chromosomal DNA. Recent studies demonstrated that TNPO3 is required for full infectivity of HIV-1. The fact that TNPO3 is a karyopherin suggests that it acts by directly promoting nuclear entry of HIV-1. Some studies support this hypothesis, while others have failed to do so....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.