Transportin 3 promotes a nuclear maturation step required for efficient HIV-1 integration.

Abstract excerpt

The HIV/AIDS pandemic is a major global health threat and understanding the detailed molecular mechanisms of HIV replication is critical for the development of novel therapeutics. To replicate, HIV-1 must access the nucleus of infected cells and integrate into host chromosomes, however little is known about the events occurring post-nuclear entry but before integration. Here we show that the karyopherin...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Active Transport, Cell Nucleus
• Share to beta Karyopherins