Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impairment of human immunodeficiency virus type-1 integrase SUMOylation correlates with an early replication defect.

The Journal of biological chemistry - 10 Jun 2011

Zamborlini Alessia, Coiffic Audrey, Beauclair Guillaume, Delelis Olivier, Paris Joris, Koh Yashuiro, Magne Fabian, Giron Marie-Lou, Tobaly-Tapiero Joelle, Deprez Eric, Emiliani Stephane, Engelman Alan, de Thé Hugues, Saïb Ali

Abstract excerpt

HIV-1 integrase (IN) orchestrates the integration of the reverse transcribed viral cDNA into the host cell genome and participates also in other steps of HIV-1 replication. Cellular and viral factors assist IN in performing its multiple functions, and post-translational modifications contribute to modulate its activities. Here, we show that HIV-1 IN is modified by SUMO proteins and that phylogenetically conserved...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HEK293 Cells
Share to HeLa Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Infections

Share to HIV Integrase

Share to Reverse Transcription

Share to Sumoylation

Share to Virus Integration

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 21454548
DOI: 10.1074/jbc.M110.189274
PMCID: PMC3121452

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impairment of human immunodeficiency virus type-1 integrase SUMOylation correlates with an early replication defect.PMID 21454548Read ↗

Mutations altering acetylated residues in the CTD of HIV-1 integrase cause defects in proviral transcription at early times after integration of viral DNA.Semantic proximity Read ↗

Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis.Semantic proximity Read ↗

Going beyond Integration: The Emerging Role of HIV-1 Integrase in Virion MorphogenesisSemantic proximity Read ↗

The Involvement of Ubiquitination and SUMOylation in Retroviruses Infection and LatencySemantic proximity Read ↗

Ubiquitination and SUMOylation in HIV Infection: Friends and FoesSemantic proximity Read ↗

Human Immunodeficiency Virus Type 1 Integrase Protein Promotes Reverse Transcription through Specific Interactions with the Nucleoprotein Reverse Transcription ComplexSemantic proximity Read ↗

A point mutation in HIV-1 integrase redirects proviral integration into centromeric repeatsSemantic proximity Read ↗

Viral manipulation of the cellular sumoylation machinerySemantic proximity Read ↗

Sequential Deletion of the Integrase (Gag-Pol) Carboxyl Terminus Reveals Distinct Phenotypic Classes of Defective HIV-1Semantic proximity Read ↗

Emergence of Compensatory Mutations Reveals the Importance of Electrostatic Interactions between HIV-1 Integrase and Genomic RNA.Semantic proximity Read ↗

Post-translational Modification-Based Regulation of HIV ReplicationSemantic proximity Read ↗

Mutations in the catalytic core or the C-terminus of murine leukemia virus (MLV) integrase disrupt virion infectivity and exert diverse effects on reverse transcription.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.