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Article

Mutations affecting interaction of integrase with TNPO3 do not prevent HIV-1 cDNA nuclear import.

Retrovirology - 16 Dec 2011

Cribier Alexandra, Ségéral Emmanuel, Delelis Olivier, Parissi Vincent, Simon Aurélie, Ruff Marc, Benarous Richard, Emiliani Stéphane

Abstract excerpt

BACKGROUND: Integration of human immunodeficiency virus type 1 (HIV-1) into a host cell chromosome is an essential step under the control of the viral integrase (IN). Although this enzyme is necessary and sufficient to catalyze the integration reaction in vitro, cellular cofactors are involved in the process in vivo. The chromatin-associated factor LEDGF/p75 interacts with IN and promotes integration to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22176773
DOI: 10.1186/1742-4690-8-104
PMCID: PMC3286403

Genes

TNPO3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Mutations affecting interaction of integrase with TNPO3 do not prevent HIV-1 cDNA nuclear import.PMID 22176773Read ↗

The HIV-1 integrase mutant R263A/K264A is 2-fold defective for TRN-SR2 binding and viral nuclear import.Semantic proximity Read ↗

The karyophilic properties of human immunodeficiency virus type 1 integrase are not required for nuclear import of proviral DNA.Semantic proximity Read ↗

Inhibition of HIV-1 infection by TNPO3 depletion is determined by capsid and detectable after viral cDNA enters the nucleus.Semantic proximity Read ↗

Identification of the LEDGF/p75 HIV-1 integrase-interaction domain and NLS reveals NLS-independent chromatin tethering.Semantic proximity Read ↗

The Cell Cycle Independence of HIV Infections Is Not Determined by Known Karyophilic Viral ElementsSemantic proximity Read ↗

Human Immunodeficiency Virus Type 1 Integrase Protein Promotes Reverse Transcription through Specific Interactions with the Nucleoprotein Reverse Transcription ComplexSemantic proximity Read ↗

Contribution of the C-terminal tri-lysine regions of human immunodeficiency virus type 1 integrase for efficient reverse transcription and viral DNA nuclear import.Semantic proximity Read ↗

Importin α3 Interacts with HIV-1 Integrase and Contributes to HIV-1 Nuclear Import and ReplicationSemantic proximity Read ↗

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Identification of critical motifs within HIV-1 integrase required for importin α3 interaction and viral cDNA nuclear import.Semantic proximity Read ↗

Reversion of the lethal phenotype of an HIV-1 integrase mutant virus by overexpression of the same integrase mutant protein.Semantic proximity Read ↗

LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells.Semantic proximity Read ↗

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